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・ Small nucleolar RNA snoR60
・ Small nucleolar RNA snoR639/H1
・ Small nucleolar RNA snoR86
・ Small nucleolar RNA snoR9
・ Small nucleolar RNA snoR9 plant
・ Small nucleolar RNA snoR98
・ Small nucleolar RNA SNORA1
・ Small nucleolar RNA SNORA11
・ Small nucleolar RNA SNORA12
・ Small nucleolar RNA SNORA13
・ Small nucleolar RNA SNORA14
・ Small nucleolar RNA SNORA15
・ Small nucleolar RNA SNORA17
・ Small nucleolar RNA SNORA18
・ Small nucleolar RNA SNORA19
Small nucleolar RNA SNORA2
・ Small nucleolar RNA SNORA20
・ Small nucleolar RNA SNORA21
・ Small nucleolar RNA SNORA22
・ Small nucleolar RNA SNORA24
・ Small nucleolar RNA SNORA25
・ Small nucleolar RNA SNORA26
・ Small nucleolar RNA SNORA27
・ Small nucleolar RNA SNORA28
・ Small nucleolar RNA SNORA29
・ Small nucleolar RNA SNORA30
・ Small nucleolar RNA SNORA32
・ Small nucleolar RNA SNORA33
・ Small nucleolar RNA SNORA35
・ Small nucleolar RNA SNORA38


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Small nucleolar RNA SNORA2 : ウィキペディア英語版
Small nucleolar RNA SNORA2

In molecular biology, SNORA2 (also known as ACA2) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
ACA2 was originally cloned from HeLa cells by association with GAR1 protein. It has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs. Originally two sequence variants of ACA2 were identified (called ACA2a and ACA2b). Both variants share approximately 66% sequence identity to another snoRNA characterised in the same study called ACA34 (also known as SNORA34). In the human genome all three snoRNAs (ACA2a, ACA2b and ACA34) are found to be located in the introns of the same gene. This gene encodes a predicted protein referred to as FLJ20436.〔
Both variants of ACA2 have the same two predicted target sites (U4263 and U4282) in 28S ribosomal RNA (rRNA). ACA34 is also predicted to target one of these sites (U4282) in addition to U4269 of 28S rRNA.〔 The sequence similarity, genomic location and the predicted target sites of these three snoRNAs suggest they have been generated by subsequent gene duplications during evolution.〔
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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